CAS Seminar

Innocent Kwizera

(Jacobs University)

"Modeling and simulation of bone remodeling"

Date: Thu, May 10, 2012
Time: 9:45
Place: Research I Seminar Room

Abstract: The architecture of trabecular bone is thought to be an optimal mechanical structure in terms of maximal strength and stiffness, and minimal weight. The structural optimality seems to be maintained during growth and adulthood by adaptation of mass and structure through a relationship with actual mechanical usage. The formation and maintenance of the architecture is realized by bone-resorbing osteoclasts and bone-forming osteoblasts. Hence, a feedback regulatory mechanism between external loads and metabolism must exist. In the talk, we will specify the mathematical background of the model for the workings of such regulatory schemes and show some preliminary results.